Alexandre M. Erkine
Associate Professor,
College of Pharmacy and Health Sciences
Butler University
4600 Sunset Avenue
Indianapolis, IN 46208-3485
Phone: 317-940-8569
Fax: 317-940-6172
Email: aerkine@butler.edu
Associate Professor,
College of Pharmacy and Health Sciences
Butler University
4600 Sunset Avenue
Indianapolis, IN 46208-3485
Phone: 317-940-8569
Fax: 317-940-6172
Email: aerkine@butler.edu
Ph.D. in Biochemistry, St. Petersburg State University, Russia
Postdoctoral training: The Netherlands, Canada, USA
1998-2003 Research Assistant Professor (LSU Health Sciences Center)
2003-2009 Assistant Professor (USD Sanford School of Medicine)
2009 -presnt Associate Professor (COPHS, Butler University, Indianapolis)
Teaching: Medical Biochemistry, Molecular Biology, Molecular Pharmacology, Pharmacological Biotechnology, Biopharmaceutical Analysis
Research interests: new drug discovery, drug development, gene expression, chromatin dynamics.
Drug discovery project at Butler University: Recent developments indicate that a molecular chaperone system is actively involved in cancerogenesis, neurodegeneration and cardiovascular disorders. The master regulator of molecular chaperone expression at the level of transcription is the heat shock factor (HSF). Development of drugs activating or repressing HSF is an important pharmacological goal. The objectives of our project include the creation of yeast strains that later will be utilized in high-throughput screens of chemical libraries for compounds affecting the HSF function. It will require engineering new gene reporter constructs and evaluating screening systems with known HSF affecting compounds.
Primary scientific directions are focused on the investigation of gene regulation mechanisms affecting the expression of molecular chaperones. Molecular chaperones are cellular components involved in cancerogenesis, and are important for cell survival during cardiovascular and neurodegenerative disorders. One of the goals is to initiate a drug discovery project looking for compounds affecting activators of molecular chaperone expression.
Postdoctoral training: The Netherlands, Canada, USA
1998-2003 Research Assistant Professor (LSU Health Sciences Center)
2003-2009 Assistant Professor (USD Sanford School of Medicine)
2009 -presnt Associate Professor (COPHS, Butler University, Indianapolis)
Teaching: Medical Biochemistry, Molecular Biology, Molecular Pharmacology, Pharmacological Biotechnology, Biopharmaceutical Analysis
Research interests: new drug discovery, drug development, gene expression, chromatin dynamics.
Drug discovery project at Butler University: Recent developments indicate that a molecular chaperone system is actively involved in cancerogenesis, neurodegeneration and cardiovascular disorders. The master regulator of molecular chaperone expression at the level of transcription is the heat shock factor (HSF). Development of drugs activating or repressing HSF is an important pharmacological goal. The objectives of our project include the creation of yeast strains that later will be utilized in high-throughput screens of chemical libraries for compounds affecting the HSF function. It will require engineering new gene reporter constructs and evaluating screening systems with known HSF affecting compounds.
Primary scientific directions are focused on the investigation of gene regulation mechanisms affecting the expression of molecular chaperones. Molecular chaperones are cellular components involved in cancerogenesis, and are important for cell survival during cardiovascular and neurodegenerative disorders. One of the goals is to initiate a drug discovery project looking for compounds affecting activators of molecular chaperone expression.